Friday, August 26, 2011

Dimetapp Nighttime Flu Suspension


Pronunciation: a-SEET-a-MIN-oh-fen/KLOR-fen-EER-a-meen/DEX-troe-meth-OR-fan/FEN-il-EF-rin
Generic Name: Acetaminophen/Chlorpheniramine/Dextromethorphan/Phenylephrine
Brand Name: Examples include Dimetapp Nighttime Flu and Tylenol Children's Plus Flu


Dimetapp Nighttime Flu Suspension is used for:

Relieving symptoms of pain, sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also used for other conditions as determined by your doctor.


Dimetapp Nighttime Flu Suspension is a decongestant, antihistamine, cough suppressant, and analgesic combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The analgesic and cough suppressant work in the brain to decrease pain and to reduce a dry or unproductive cough.


Do NOT use Dimetapp Nighttime Flu Suspension if:


  • you are allergic to any ingredient in Dimetapp Nighttime Flu Suspension

  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

  • you are unable to urinate or are having an asthma attack

  • you take sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Dimetapp Nighttime Flu Suspension:


Some medical conditions may interact with Dimetapp Nighttime Flu Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a fast, slow, or irregular heartbeat

  • if you have a history of adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; blood vessel problems; stroke; glaucoma; a blockage of your stomach, bladder, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; seizures; an overactive thyroid; liver problems; or severe kidney problems; or if you drink 3 or more drinks with alcohol per day

  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

  • if you smoke or have a history of addiction to alcohol

Some MEDICINES MAY INTERACT with Dimetapp Nighttime Flu Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) they may increase the risk of Dimetapp Nighttime Flu Suspension's side effects

  • Anticoagulants (eg, warfarin), digoxin, or droxidopa because risk of bleeding, irregular heartbeat, or heart attack may be increased

  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Dimetapp Nighttime Flu Suspension

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Dimetapp Nighttime Flu Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dimetapp Nighttime Flu Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Dimetapp Nighttime Flu Suspension:


Use Dimetapp Nighttime Flu Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Dimetapp Nighttime Flu Suspension by mouth with or without food.

  • Shake well before each use.

  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • If you miss a dose of Dimetapp Nighttime Flu Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dimetapp Nighttime Flu Suspension.



Important safety information:


  • Dimetapp Nighttime Flu Suspension may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Dimetapp Nighttime Flu Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not drink alcohol while you use Dimetapp Nighttime Flu Suspension.

  • Do not take diet or appetite control medicines while you use Dimetapp Nighttime Flu Suspension unless your doctor tells you otherwise.

  • Dimetapp Nighttime Flu Suspension contains acetaminophen, chlorpheniramine, dextromethorphan, and phenylephrine. Before you start any new medicine, check the label to see if it has any of these medicines in it. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do not use Dimetapp Nighttime Flu Suspension for a cough with a lot of mucous. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.

  • Do NOT take more than the recommended dose or take Dimetapp Nighttime Flu Suspension for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 5 days or if they get worse, check with your doctor.

  • Contact your doctor if you have a sore throat that is severe, lasts more than 2 days, or occurs with fever, rash, headache, nausea, or vomiting.

  • Contact your doctor if you have a fever that lasts for more than 3 days.

  • Dimetapp Nighttime Flu Suspension may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Dimetapp Nighttime Flu Suspension. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Dimetapp Nighttime Flu Suspension may harm your liver. Your risk may be greater if you drink alcohol while you are using Dimetapp Nighttime Flu Suspension. Talk to your doctor before you take Dimetapp Nighttime Flu Suspension or other fever reducers if you drink more than 3 drinks with alcohol per day.

  • Dimetapp Nighttime Flu Suspension may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Dimetapp Nighttime Flu Suspension for a few days before the tests.

  • Tell your doctor or dentist that you take Dimetapp Nighttime Flu Suspension before you receive any medical or dental care, emergency care, or surgery.

  • Use Dimetapp Nighttime Flu Suspension with caution in the ELDERLY; they may be more sensitive to its effects.

  • Caution is advised when using Dimetapp Nighttime Flu Suspension in CHILDREN; they may be more sensitive to its effects, especially excitability.

  • Different brands of Dimetapp Nighttime Flu Suspension may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dimetapp Nighttime Flu Suspension while you are pregnant. It is not known if Dimetapp Nighttime Flu Suspension is found in breast milk. Do not breast-feed while taking Dimetapp Nighttime Flu Suspension.


Possible side effects of Dimetapp Nighttime Flu Suspension:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; diarrhea; dizziness; drowsiness; excitability; headache; trouble sleeping; upset stomach.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; vision changes; yellowing of skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Dimetapp Nighttime Flu side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Dimetapp Nighttime Flu Suspension:

Store Dimetapp Nighttime Flu Suspension at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dimetapp Nighttime Flu Suspension out of the reach of children and away from pets.


General information:


  • If you have any questions about Dimetapp Nighttime Flu Suspension, please talk with your doctor, pharmacist, or other health care provider.

  • Dimetapp Nighttime Flu Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Dimetapp Nighttime Flu Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Dimetapp Nighttime Flu resources


  • Dimetapp Nighttime Flu Side Effects (in more detail)
  • Dimetapp Nighttime Flu Use in Pregnancy & Breastfeeding
  • Dimetapp Nighttime Flu Drug Interactions
  • 0 Reviews for Dimetapp Nighttime Flu - Add your own review/rating


Compare Dimetapp Nighttime Flu with other medications


  • Cold Symptoms
  • Cough
  • Cough and Nasal Congestion
  • Nasal Congestion
  • Pain/Fever
  • Rhinorrhea
  • Sinus Symptoms


Wednesday, March 9, 2011

Diphenhydramine and phenylephrine


Generic Name: diphenhydramine and phenylephrine (DYE fen HYE dra meenand FEN il EFF rin)

Brand names: Alahist LQ, Aldex-CT, Children's Triacting Night Time, D-Tann, Dimetapp Nighttime Cold & Congestion, Diphenmax D, Dytan-D, PediaCare Children's Allergy & Cold, Robitussin Night Time Cough & Cold, Robitussin Night Time Cough & Cold Children's, Robitussin Night Time Cough & Cold Pediatric, Triaminic Night Time Cold & Cough, ...show all 23 brand names.


What is diphenhydramine and phenylephrine?

Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


The combination of diphenhydramine and phenylephrine is used to treat runny or stuffy nose, sneezing, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.


Diphenhydramine and phenylephrine may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about diphenhydramine and phenylephrine?


Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. Avoid drinking alcohol while you are taking this medication. It can add to drowsiness caused by an antihistamine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.


This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by diphenhydramine.

What should I discuss with my healthcare provider before taking diphenhydramine and phenylephrine?


You should not use this medication if you are allergic to diphenhydramine or phenylephrine.

Before taking this medication, tell your doctor if you are allergic to any drugs, or if you have:



  • asthma;




  • heart disease or high blood pressure;




  • diabetes;




  • a thyroid disorder;




  • glaucoma;




  • kidney disease;




  • an enlarged prostate; or




  • problems with urination.



If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.


This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.

Artificially-sweetened liquid forms of cold medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.


How should I take diphenhydramine and phenylephrine?


Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.


Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.


Make sure you chew the chewable tablet before you swallow it.


This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.


Store this medicine at room temperature, away from heat, light, and moisture.

What happens if I miss a dose?


Since cold or allergy medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).


What should I avoid while taking diphenhydramine and phenylephrine?


Avoid drinking alcohol while you are taking this medication. It can add to drowsiness caused by an antihistamine. Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by diphenhydramine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.


This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.


Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. Antihistamines, decongestants, and cough suppressants are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

Diphenhydramine and phenylephrine side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;




  • confusion, hallucinations, unusual thoughts or behavior;




  • urinating less than usual or not at all;




  • severe dizziness, anxiety, restless feeling, or nervousness;




  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;




  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or




  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).



Less serious side effects may include:



  • blurred vision;




  • dry mouth;




  • nausea, stomach pain, constipation;




  • dizziness, drowsiness;




  • problems with memory or concentration;




  • ringing in your ears;




  • mild loss of appetite;




  • warmth, tingling, or redness under your skin;




  • feeling excited or restless;




  • sleep problems (insomnia); or




  • skin rash or itching.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Diphenhydramine and phenylephrine Dosing Information


Usual Adult Dose for Allergic Rhinitis:

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Adult Dose for Cold Symptoms:

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Adult Dose for Sinusitis:

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Pediatric Dose for Allergic Rhinitis:

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Usual Pediatric Dose for Cold Symptoms:

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Usual Pediatric Dose for Sinusitis:

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue


What other drugs will affect diphenhydramine and phenylephrine?


Tell your doctor about all other medications you use, especially:



  • medicines to treat high blood pressure;




  • a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others;




  • antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others; or




  • an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).



This list is not complete and there may be other drugs that can interact with diphenhydramine and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



More diphenhydramine and phenylephrine resources


  • Diphenhydramine and phenylephrine Side Effects (in more detail)
  • Diphenhydramine and phenylephrine Use in Pregnancy & Breastfeeding
  • Drug Images
  • Diphenhydramine and phenylephrine Drug Interactions
  • Diphenhydramine and phenylephrine Support Group
  • 1 Review for Diphenhydramine and phenylephrine - Add your own review/rating


Compare diphenhydramine and phenylephrine with other medications


  • Cold Symptoms
  • Hay Fever
  • Sinusitis


Where can I get more information?


  • Your pharmacist can provide more information about diphenhydramine and phenylephrine.

See also: diphenhydramine and phenylephrine side effects (in more detail)